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Professor Tali Cukierman-Yaffe

Chair Of Research

Professor Tali Cukierman-Yaffe

Prof. Tali Cukierman-Yaffe is an endocrinologist and a clinical epidemiologist. A senior physician in the Endocrinology Institute, the head of the Centre for Successful Aging with Diabetes at the Sheba Medical Centre, head of the Endocrinology & Diabetes service for women &n pregnancy an associate professor at the Epidemiology department at Tel-Aviv University and a member of the Herczeg institute on aging. She is also a PHRI (Population Health Research Institute, Mcmaster University, Canada) senior international fellow.

The focus of her research is the relationship between diabetes and cognitive dysfunction and the challenges of treating diabetes in older age. She has published many articles and has given numerous talks on this topic, is part of working groups writing local and international guidelines on this topic and is an invited advisor in forums dealing with this subject. Thus, she was PI of the cognitive sub-study of the ORIGIN trial, a co-investigator of the ACCORD-MIND study and took a key role in the cognitive sub-study of the REWIND trial that tested the cognitive safety and efficacy of Dulaglutide in people with diabetes. In the last several years her research has also been focused on finding technological solutions to improve the care of older people with diabetes. Thus, she is the Principal investigator of a EFSD funded study aimed at developing a technological solution for the replacement of traditional physical capacity assessments for older people with diabetes and another study aimed at developing a digital Digit Substitution Test (DSS) cognitive assessment tool.

“Aging with diabetes is a challenge. My role as a physician providing care to  older people with diabetes is to help them age in a healthy way.  It starts by assessing their cognitive & physical health agility then providing appropriate glucose, blood pressure and lipid targets and finally implementing evidence based interventions that have been shown to promote healthy aging in this population.”

Highlighted Publications

Development and first-stage validation of a digital version of the Digit Symbol Substitution test for use in assessing cognitive function in older people with diabetes

Omri Segev, Itamar Raz, Hertzel C. Gerstein ,  Hillel Aviezer,  Yael Sela,  Dani Cukierman, Rahul Shankar, Rachel Natovich, Tali Cukierman-Yaffe .

Diabetes Obesity & Metabolism,   May 17, 2024.  PMID 38757537

Effect of Basal insulin & Omega 3 Fatty Acids on Cognitive Impairment in Dysglycemia: An Exploratory Analysis of the ORIGIN Trial

Tali Cukierman-Yaffe , Chinthanie Ramasundarahettige  Jackie Bosch , Hertzel C. Gerstein.

Diabetes Obesity & Metabolism, April 26(4), 1180-1187, 2024.

PMID 38204215

Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial.

Cukierman-Yaffe T, Gerstein HC, Colhoun HM, Diaz R, García-Pérez LE, Lakshmanan M, Bethel A, Xavier D, Probstfield J, Riddle MC, Rydén L, Atisso CM, Hall S, Rao-Melacini P, Basile J, Cushman WC, Franek E, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschie

Lancet Neurol. 2020 Jul;19(7):582-590. doi: 10.1016/S1474-4422(20)30173-3. PMID: 32562683.

Characterizing Movement Patterns of Older Individuals with T2D in Free-Living Environments Using Wearable Accelerometers.  

Yahalom-Peri, T.; Bogina V.; Basson-Shleymovich, Y.; Azmon M, Kuflik, T.; Kodesh, E.; Volpato S., Cukierman-Yaffe, T

J of Clinical Medicine Nov 29; 12(23):7404, 2023. PMID:38068456